Bacterial metabolite mediated regulation of the immune and metabolic systems [ 2018 - 2020 ]

Research Grant

Researchers: Prof Charles Mackay (Principal investigator) ,  Prof Tony Tiganis

Brief description The cellular and molecular events that underpin metabolic syndrome diseases, such as diabetes, fatty liver, etc are poorly understood. However recent advances provide new clues. First, the immune system is intimately connected to metabolism. Second, the gut microbiota, and its metabolites such as acetate and butyrate are also important. These metabolites induce epigenetic changes in cells. We will study how metabolites induce molecular changes epigenetically, and how this controls metabolism.

Funding Amount $AUD 303,374.10

Funding Scheme Targeted Calls

Notes A*STAR Joint Call for Research in Novel Molecular Mechanisms of Obesity and Metabolic Diseases