grant

ATR-X syndrome: Role of ATRX in testicular growth and spermatogenesis [ 2011 - 2013 ]

Also known as: Investigating the mechanisms underlying male infertility

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1004992]

Researchers: Dr Stefan Bagheri-Fam (Principal investigator) ,  Dr Anthony Argentaro

Brief description Infertility is surprisingly common and affects 1 in 20 Australian men. Testosterone and its receptor, the androgen receptor, are well known to be essential for spermatogenesis and fertility. We have identified an important regulator protein (ATRX) of androgen receptor activity and show that loss of function of ATRX in testes of mice leads to spermatogenesis defects. Identifying the molecular action of ATRX will lead to a better understanding of the underlying causes of infertility in men.

Funding Amount $AUD 650,881.36

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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