ATP synthase: Regulation, antibiotics and mitochondrial disease [ 2019 - ]

Research Grant

Researchers: Dr Alastair Stewart (Principal investigator)

Brief description ATP synthase is an essential large biological enzyme that generates large amounts of cellular energy. Mutations in ATP synthase are important in many medical mitochondrial pathologies, including cardiomyopathies, heart failure and dementia. This proposal aims to image this essential enzyme at the atomic scale and exploit this knowledge to develop novel antibiotics and to understand how mutations in its components generate mitochondrial diseases.

Funding Amount $437,036.00

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF