grant

Astrocytic glutamate transporters: molecular characteristics of their activity-dependent localization and targeting [ 2008 - 2010 ]

Also known as: Pharmacological regulation of the function of glutamate tranporters

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/509319]

Researchers: Prof Philip Beart (Principal investigator) ,  Dr Ross O'Shea

Brief description Dysfunction of glutamate transport is implicated in the pathology of neurodegenerative conditions. Our aim is to understand how the molecules responsible for glutamate transport are organized on the cell surface and how their movement within cells regulates transporter activity. Advances of this type will indicate new pharmacological and molecular biological strategies for the management of brain disorders.

Funding Amount $AUD 558,189.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Related Publications

  • Associated with LINKS BETWEEN L-GLUTAMATE TRANSPORTERS, NA(+)/K+-ATPASE AND CYTOSKELETON IN ASTROCYTES: EVIDENCE FOLLOWING INHIBITION WITH ROTTLERIN
    handle : 11343/43848
  • Associated with Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin
    handle : 11343/41929

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Carbohydrates | Medical Biochemistry and Metabolomics | astrocytes | cell culture | excitatory amino acids | glutamate metabolism | membrane transport | molecular pharmacology | neurodegeneration | neuroinflammation | protein trafficking | therapeutic target |
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