Assessment of Vestibular Function and Balance in Humans [ 2004 - 2006 ]

Research Grant

Researchers: Prof James Colebatch (Principal investigator)

Brief description This proposal focuses upon the function of the vestibular apparatus and the related problem of impaired balance. The vestibular apparatus contains receptors which help us to maintain balance. Their clinical assessment is difficult because they are small and lie deep within the skull. With previous NH and MRC support, I have been able to develop a series of new tests to assess the function of the vestibular apparatus and these are having significant clincal impact. Amongst the findings has been a clear demonstration that vestibular function declines with age, starting relatively early. This proposal builds upon the findings of the previous application. Two main types of investigations are planned. In one a new technique of activating the vestibular apparatus (localised skull vibration) will be used to study the brain areas that receive its signals (evoked potentials). This will be the first time that it has been possible to study the connections between the balance organs and the cortex of the brain in intact humans. I will apply the technique to patients with disturbed vestibular function to improve our knowledge of how the brain adapts to disease of these organs. In the second part of this study, a series of recordings will be done measuring sway under a variety of conditions both in normal volunteers and in patients with some common disease states affecting balance. This should reveal new information about both the factors that affect normal balance function and why balance is disturbed in these diseases.

Funding Amount $AUD 205,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant