ASSESSMENT OF ENDOPLASMIC RETICULUM STRESS AND MUTATIONS IN MUCIN OLIGOMERIZATION DOMAINS IN ULCERATIVE COLITIS [ 2008 - 2010 ]

Research Grant

Researchers: Prof Timothy Florin (Principal investigator) ,  A/Pr Graham Radford-Smith ,  Dr Elizabeth Fowler ,  Dr Rajaraman Eri ,  Prof Michael Mcguckin

Brief description Ulcerative colitis affects 0.2% of Australians causing chronic or recurrent health morbidity and affecting employment. In severe cases it is life threatening. Its pathogenesis remains poorly understood. We have exciting and novel preliminary data from humans and informed by our unique animal models that make us propose that the disease is caused by Endoplasmic Reticulum Stress due to misfolding of mucin. We have designed fully powered prospective clinical and lab studies to test this hypothesis.

Funding Amount $AUD 292,216.81

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant