Assembly and misassembly of mitochondrial respiratory chain Complex I [ 2017 - 2019 ]

Research Grant

Researchers: Prof Michael Ryan (Principal investigator) ,  Prof David Thorburn

Brief description Mitochondria are the powerhouses in our cells. They burn the carbon fuels we eat and store the energy by making ATP that is used for functions such as muscle contraction and triggering of nerves. Mitochondrial Complex I is a molecular motor that helps to make ATP. “Mitochondrial disease” is often seen when Complex I is not built properly and this results in early childhood death. In this project we will study how Complex I is built and how the mitochondria responds to assembly problems.

Funding Amount $AUD 533,568.43

Funding Scheme Project Grants

Notes Standard Project Grant