Assembly and function of two interacting oncogenic scaffolds [ 2018 - 2020 ]

Research Grant

Researchers: Dr Isabelle Lucet (Principal investigator) ,  A/Pr James Murphy ,  Prof Roger Daly

Brief description Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.

Funding Amount $AUD 715,463.19

Funding Scheme Project Grants

Notes Standard Project Grant