Aromatase regulation by p53 and HIF-1alpha in obesity and post-menopausal breast cancer. [ 2011 - 2013 ]

Research Grant

Researchers: Kristy Brown (Principal investigator) ,  Dr Olivier Latchoumanin ,  Prof Evan Simpson ,  Prof Stephen Fox

Brief description Current hormone therapy for breast cancer using inhibitors of oestrogen production results in serious side-effects including bone loss, joint pain and possibly cognitive issues. Our current work is aimed at understanding how oestrogen production is regulated with the goal of developing breast-specific inhibitors of oestrogen production to obviate these problems. In addition, this work is aimed at devising therapeutic intervention to break the linkage between obesity and breast cancer.

Funding Amount $AUD 607,523.03

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant