ARC Future Fellowships - Grant ID: FT230100084 [ 2023-07-01 - 2027-06-30 ]

Research Grant

Researchers: Dr Frank Sainsbury (Future Fellowship) ,  Dr Frank Sainsbury (Future Fellowship)

Brief description Developing a new class of RNA delivery vehicle using synthetic virology. This project aims to develop robust protein cages derived from the empty shells of viruses, or capsids, to protect and deliver sensitive cargo such as RNA in agricultural settings. It will do so by directed evolution of non-infectious capsids in the lab. This will uncover the molecular mechanisms underpinning the response of viruses to chemical and biological signals and create a new class of RNA delivery vehicle. This synthetic biology approach combines virology and protein engineering to establish a platform biotechnology for stable and effective delivery. The project expects to demonstrate the potential of nature’s nanoparticles, virus capsids, to enhance the efficacy of RNA technologies in a wide range of applications.

Funding Amount $968,816

Funding Scheme ARC Future Fellowships

View this grant in the ARC Data Portal