Research Grant
[Cite as https://purl.org/au-research/grants/arc/FT130100580]Researchers: Dr Begona Heras (Future Fellowship )
Brief description How Bacteria Fold Virulence Factors to Cause Disease. Bacteria use folding enzymes to assemble proteins essential for cell integrity and pathogenicity. These foldases include the Disulphide bridge proteins, which catalyse the introduction of disulfide bonds. This project will study two important human pathogens, Salmonella Typhimurium and uropathogenic Escherichia coli, to address the fundamental and poorly understood questions of diversity of Dsb networks across bacterial pathogens and the role of these foldases in virulence. The research will reveal how bacterial virulence factors are folded, identify novel targets for therapeutic intervention and provide the basis for structure-based design on new antimicrobials in the future.
Funding Amount $749,153
Funding Scheme ARC Future Fellowships
- PURL : https://purl.org/au-research/grants/arc/FT130100580
- ARC : FT130100580