grant

Apoptotic pathways in pancreatic beta cells leading to type 1 diabetes and transplant rejection [ 2008 - 2010 ]

Also known as: Cell death pathways in pancreatic beta cells

Funded by National Health and Medical Research Council
Managed by St. Vincent's Institute of Medical Research
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/502605]

Researchers: A/Pr Helen Thomas (Principal investigator) ,  Dr Janette Allison ,  Prof Thomas Kay

Brief description The destruction of insulin-producing beta cells in the pancreas by immune cells leads to the need for daily insulin injections in patients with type 1 diabetes. This project aims to understand how beta cells are destroyed. A knowledge of the process by which this occurs will indicate ways we can protect these cells. Our previous work has suggested strategies that may protect beta cells, and we aim to test these. Such protection may eventually allow beta cell replacement by transplantation.

Funding Amount $AUD 535,333.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Autoimmunity | Biomedical and Clinical Sciences | Clinical Sciences | Emergency Medicine | Islet Transplantation | NOD mouse | Type 1 Diabetes | apoptosis | cytotoxic T cell | pancreatic beta cell | type 1 diabetes |
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