grant

Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease. [ 2013 - 2015 ]

Also known as: Targetting of a common signalling pathway in the pathogenesis of different types of progressive kidney disease.

Funded by National Health and Medical Research Council
Managed by Monash University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1044289]

Researchers: A/Pr David Nikolic-Paterson (Principal investigator) ,  A/Pr Greg Tesch

Brief description Oxidative stress plays an important role in progressive kidney disease. We have identified a stress-activated mechanism (the ASK1 pathway) through which oxidative stress may cause kidney disease. We will perform preclinical studies in models of different types of kidney disease with an ASK1 inhibitor drug and genetically modified mice. These studies will provide new insights into the pathogenesis of kidney disease and will determine the potential of ASK1 as therapeutic target in kidney disease.

Funding Amount $AUD 678,865.69

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Clinical Sciences | Medical and Health Sciences | Nephrology and Urology | diabetic nephropathy | glomerular inflammation | glomerulosclerosis | kinase inhibitors | pathogenic mechanisms | renal interstitial fibrosis | signalling pathways |
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