Apo2L/TRAIL killing of tumour cells and the role of Inhibitor of Apoptosis proteins [ 2007 - 2009 ]

Research Grant

Researchers: Prof John Silke (Principal investigator)

Brief description Melanomas and Gliomas are tumour types that respond poorly to current treatments. Current treatments are not only sometimes ineffective, but also unpleasant and may cause co-lateral damage. We will test 2 new targetted anti-cancer treatments, that so far appear to have minor side effects in small animal models, on these difficult to treat tumour types to see if and how they kill them. We also want to know whether these independent treatments can work together to kill tumours more effectively. Although we will not personally test these drugs in clinical settings, these drugs or similar are currently in preclinical and clinical trials. This means that understanding how these drugs function is of paramount importance and may result in better clinical trials and possibly more rapid acceptance of the use of these drugs in patients.

Funding Amount $AUD 390,321.74

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant