APLP2: a neuroprotective receptor for acute brain injury [ 2017 - 2019 ]

Research Grant

Researchers: Prof Roberto Cappai (Principal investigator) ,  A/Pr Peter Crack

Brief description Traumatic brain injury (TBI) is the major cause of deaths in Australians under 45 years of age. We have shown that the amyloid precursor protein (APP) is protective in models of TBI. To understand how APP is neuroprotective we have isolated APP binding proteins and identified the amyloid precursor-like protein 2 (APLP2) molecule as a strong candidate for the APP-neuroprotective receptor. This grant will investigate the interaction between APP and APLP2 as a novel neuroprotective pathway in TBI.

Funding Amount $AUD 664,292.24

Funding Scheme Project Grants

Notes Standard Project Grant