ANTIVIRAL DRUG RESISTANT HBV: PATHOGENIC AND ONCOGENIC SIGNIFICANCE OF THE ALTERED VIRAL ENVELOPE [ 2011 - 2014 ]

Research Grant

Researchers: Prof Stephen Locarnini (Principal investigator) ,  Dr Nadia Warner ,  Prof Alexander Thompson ,  Prof Kumar Visvanathan ,  Prof Peter Angus

Brief description We aim to investigate the consequences of long-term therapy for hepatitis B on liver cancer progression. We propose that antiviral therapy is associated with persistent expression and accumulation of potentially oncogenic surface proteins in the liver. This can dramatically alter the viral lifecycle, particularly the HBsAg secretion pathway, which can cause serious effects in the host hepatocyte biology, including promoting pathways to tumour formation.

Funding Amount $AUD 509,284.09

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant