Antigen receptor as oncogene: understanding CARD11 mutations in B cell malignancy [ 2014 - 2016 ]

Research Grant

Researchers: Dr Keisuke Horikawa (Principal investigator) ,  The Australian National University (Managed by)

Brief description More than 5000 Australians are newly diagnosed as lymphomas. Recent technology identified many candidate genes for lymphomas, however it still remains unclear how each mutated gene distorts signalling molecules inside tumours cells. By introducing one of recurrent mutated genes, CARD11 into mouse B cells, we will examine how this mutation affects normal signalling pathways and B cell functions. We hope this project will provide a guidance to use forthcoming drugs to target specific molecules.

Funding Amount $AUD 607,395.52

Funding Scheme Project Grants

Notes New Investigator Grant