ANTIGEN PRESENTATION IN CEREBRAL MALARIA PATHOGENESIS: A ROLE FOR BRAIN MICROVASCULAR ENDOTHELIUM AND MICROPARTICLES [ 2016 - 2018 ]

Research Grant

Researchers: Prof Georges Grau (Principal investigator) ,  Dr Bernadette Saunders ,  Dr Valery Combes ,  E/Pr Nicholas Hunt

Brief description We want to better understand how lesions occur in the brain during cerebral malaria. We focus our attention on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. We already showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.

Funding Amount $AUD 427,626.16

Funding Scheme Project Grants

Notes Standard Project Grant