grant

Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity [ 2012 - 2015 ]

Also known as: Understanding anthracycline induced cardiotoxicity

Funded by National Health and Medical Research Council
Managed by University of Canberra
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1021342]

Researchers: A/Pr Nicole Beard (Principal investigator) ,  A/Pr Anneke Blackburn ,  E/Pr Angela Dulhunty ,  Prof Leonard Arnolda

Brief description Anthracyclines are one of the most effective drugs used in chemotherapy, but cause side effects resulting in serious heart problems which can be fatal. The link between anthracycline therapy and the problems they cause in the heart is not fully defined. We will investigate mechanisms leading to these side effects and define specific targets of anthracyclines in the heart. It is hoped this will lead to the design of new drugs which counteract the side effects of anthracycline treatment.

Funding Amount $AUD 525,620.39

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Cardiorespiratory Medicine and Haematology | Cardiology (Incl. Cardiovascular Diseases) | Medical and Health Sciences | arrhythmia | calcium binding proteins | calcium channels | calcium homeostasis | calcium signalling | cardiac contraction | cardiac dysfunction | cardiac muscle | ion channels | toxicology |
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