Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/316959]Researchers: Prof Robert Saint (Principal investigator) , Dr Michael Murray , The Australian National University (Managed by)
Brief description A critical step in the progression of cancers that are derived from epithelial tissues is a transition from an epithelial cell type to a migratory mesenchymal cell type that can spread to other parts of the body. This change in cell behaviour also occurs, apparently by a similar mechanism, during the development of some normal tissue types. Here we propose to use an animal model of this process, coupled with advanced molecular genetic and cell biological techniques, to investigate a newly discovered cell signalling mechanism required for the transition of cells from an epithelial form to a mesenchymal form. Understanding the molecular steps in this new pathway and discovering new genes involved will provide tools for understanding and preventing the metastasis of cancer cells.
Funding Amount $AUD 409,500.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 316959
- PURL : https://purl.org/au-research/grants/nhmrc/316959
