[Cite as http://purl.org/au-research/grants/nhmrc/602516]
Prof John Silke
Prof Henning Walczak
Brief description The aim of this project to discover the role of a novel ubiquitin ligase complex that regulates TNF superfamily signalling. It will increase understanding of the TNF pathway and improve our ability to manipulate it pharmacologically, or otherwise, in the large number of debilitating human diseases including Rheumatoid Arthritis and Crohn's disease that result from aberrant TNF signalling. Because of the role of TNF in tumorigenesis it may also contribute to novel anti-cancer treatments.
Funding Amount $AUD 568,861.04
Funding Scheme NHMRC Project Grants
Standard Project Grant