Analysis of functional role of the BDNF precursor in sensory neurons [ 2006 - 2008 ]

Research Grant

Researchers: Prof Xin-Fu Zhou (Principal investigator) ,  E/Pr Robert Rush

Brief description Neurotrophins, which are generated from their precursors, are essential for the survival and function of the nervous system. One of neurotrophins, brain derived neurotrophic factor (BDNF), is made in sensory neurons and transported towards nerve terminals. Mutation of a single amino acid in the precursor of BDNF disrupts this transport. This project will examine whether the precursor of BDNF has any function within sensory nerves. We will examine whether the precursor of BDNF gets into the nerve via its receptors and whether it plays any role in the development of pain and maintenance of neuropathic pain after nerve injury. Successful execution of the project will eludicate mechanisms of pain, especially neuropathic pain, and will provide important information to assist in the design of drugs for neurological diseases.

Funding Amount $AUD 457,267.61

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant