Analysis of APC and APC protein complexes in colon cancer [ 2001 - 2003 ]

Research Grant

Researchers: Dr Maree Faux (Principal investigator) ,  Dr Bruno Catimel ,  Prof Antony Burgess

Brief description Colorectal cancer is one of the foremost causes of death in Australia. A defective form of a protein called APC has been shown to be present in more than 80% of colon tumours. How APC contributes to colon cancer is still not known. We aim to determine the function of the APC protein by studying the APC protein and proteins that interact with APC in normal and cancerous colon epithelial cells. We will use cells derived from normal colon epithelium as well as from colon carcinomas. Once we have identified proteins that interact with APC in normal colonic cells, we will have a more complete understanding of the function of APC and its role in the development of colonic tumours.

Funding Amount $AUD 110,786.72

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant