grant

An oral loading test to predict susceptibility to fluoropyrimidine drug toxicity [ 2009 - 2011 ]

Also known as: Predicting drug toxicity

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/569611]

Researchers: Dr John Duley (Principal investigator) ,  A/Pr Bruce Charles ,  A/Pr Leslie Sheffield ,  A/Pr Ross Norris ,  Dr Catherine Shannon
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Brief description Side-effects from anticancer drugs can be unpleasant, but may be deadly if a patient's genes are wrong for the drugs. A common chemotherapy drug, fluorouracil, can be very dangerous, but there's no simple way to predict this. We developed a simple test in which a small amount of a natural chemical is swallowed before chemotherapy. The results should allow the doctor to predict if a patient will suffer serious side effects on fluorouracil, so the dose can be reduced, or another drug tried.

Funding Amount $AUD 225,525.50

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Inorganic Elements and Compounds | Medical Biochemistry and Metabolomics | breast cancer | cancer chemotherapy | colorectal cancer | drug metabolism | drug toxicity | genetic polymorphisms | gynaecological cancers | pharmacokinetics | screening | side-effects |
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