grant

An immunogenomic roadmap to define drug- and tissue-relevant genetic-, cellular-, and structural-risk signatures of Stevens-Johnson syndrome/toxic epidermal necrolysis for population-personalized prevention and treatment in Australian populations.

Also known as: Ideas Grants

Funded by National Health and Medical Research Council
Managed by Murdoch University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/2028952]

Funding Amount $1,493,326.00

Full description Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis is the deadliest immune-mediated adverse drug reaction and results in severe complications such as blindness. Although genetic risk holds promise for pre-prescription screening, risk genes for Australian populations remain scarce. We will use innovative multi-omic approaches to define new genetic-, cellular-, and structural-risk signatures to improve drug safety in Australia with new strategies for prevention, diagnosis, and treatment.

Chief Investigator Dr Andrew Gibson

Date Announced 2023-12-15T00:00:00

Sector University

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Spatial Coverage And Location

text: WA

Subjects
Allergy | Basic Science Research | Immunology | Immunogenetics (Incl. Genetic Immunology) | Medical and Health Sciences | adverse drug reactions | allergy prevention | biomedical and clinical sciences | human leukocyte antigen (hla) | skin immunology | t cell receptor |
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