An analysis of a model of movement disorder lacking D1R positive neurons. [ 2000 - 2002 ]

Research Grant

Researchers: A/Pr John Drago (Principal investigator)

Brief description The experiments outlined in this project proposal are aimed at further characterizing a genetically engineered mouse the generation of which was originally funded by the Australian NH and MRC. The mutant mouse suffers from the loss of brain cells in a part of the brain called the striatum. The mouse model will allow us to understand how damage to brain structures cause disabling human neurodegenerative diseases such as Parkinsonism and Huntington's disease. The mouse model is unique as the mice suffer from the same type of movement abnormalities which afflict individuals with this spectrum of neurological illnesses. We will look at both structural changes in the brain as well as brain function as defined by the behavioural responses of the damaged brain to drug administration. The experiments also focus on the ultimate correction of the neurological deficits by transplantation of purified nerve cell progenitor cells.

Funding Amount $AUD 346,446.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant