An ace up their sleeve: characterisation of a novel family of drug efflux systems represented by the Acinetobacter AceI exporter [ 2014 - 2017 ]

Research Grant

Researchers: Prof Ian Paulsen (Principal investigator) ,  Dr Karl Hassan

Brief description Chlorhexidine is widely used as an antiseptic in products such as skin washes, soaps, mouthwashes, disinfectants and preservatives. We have recently discovered a novel bacterial protein which pumps chlorhexidine out of bacterial cells to make them resistant to this antiseptic agent. This proposal aims to understand this resistance mechanism and to find inhibitors which could be applied in clinical settings to augment the activity of chlorhexidine.

Funding Amount $AUD 400,286.49

Funding Scheme Project Grants

Notes Standard Project Grant