Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/566827]Researchers: Prof Ashley Bush (Principal investigator) , A/Pr Robert Moir , Dr James Duce
Brief description Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance. The smallest form of APP, prevalently found in the brain, is able to convert a damaging iron variety (Fe2+) into the safer Fe3+. Alternative, larger, forms of APP are found to inhibit this effect. This project will establish how APP controls iron homeostasis within brain neuronal cells and how this activity is impaired in disease, thus development a mechanism for diagnostic tests and therapeutics.
Funding Amount $AUD 949,667.34
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 566827
- PURL : https://purl.org/au-research/grants/nhmrc/566827
