How amyloid causes neurodegeneration: the role of transthyretin in familial amyloidotic polyneuropathy [ 2009 - 2011 ]

Research Grant

Researchers: Prof David Small (Principal investigator) ,  Dr Harold Coleman ,  Dr Nam Cheung ,  Prof Helena Parkington ,  Prof Marie-Isabel Aguilar

Brief description This project seeks to understand the biochemical basis of nerve degeneration in a disease known as familial amyloidotic polyneuropathy. This disease is caused by a protein known as transthyretin, which is abnormally deposited around nerves and causes nerve damage. The project is highly likely to provide clues which help us understand some related dementia causing diseases like Alzheimer's disease and prion diseases such as scrapie and mad cow disease.

Funding Amount $AUD 618,949.98

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant