Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/247913]Researchers: A/Pr Duncan Campbell (Principal investigator) , Prof Bruce Kemp
Brief description The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for matching energy supply to energy demand by the many different cells in our bodies. AMPK is active in the heart, where it may control cardiac function and the response of the heart to disease. It has been difficult to study AMPK in the heart because we lack drugs that block the actions of AMPK. This study will investigate the role of AMPK in the heart using a genetic approach whereby the AMPK enzyme is rendered inactive (a gene knockout approach). By this approach we will learn how AMPK controls heart function and how drugs that affect AMPK may impact on the heart.
Funding Amount $AUD 425,000.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 247913
- PURL : https://purl.org/au-research/grants/nhmrc/247913
