Altering macrophage phenotype for the treatment of chronic airway disease and lung cancer [ 2015 - 2018 ]

Research Grant

Researchers: Prof Matthias Ernst (Principal investigator) ,  A/Pr Steven Bozinovski

Brief description The aim of this proposal is to identify mechanisms through which the Src family kinase Hck promotes innate immune cell-dependent, chronic lung inflammation and lung cancer development. Our preliminary data suggest that excessive Hck activity provides a molecular mechanism to skew macrophage polarization towards an alternatively activated, M2-like phenotype associated with chronic airways disease, and the tumour promoting microenvironment.

Funding Amount $AUD 904,556.01

Funding Scheme Project Grants

Notes Standard Project Grant