grant

ALS4 mice show TDP-43 protein mislocalization in motor neurons characteristic of sporadic ALS patients; suggesting this model is likely to reveal important patho-mechanistic disease insights [ 2013 - 2014 ]

Also known as: ALS4 mice carrying SETX gene mutations may help us understand motor neurone disease in general

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1045520]

Researchers: Dr Craig Bennett (Principal investigator) ,  Dr Albert La Spada

Brief description SETX gene mutations cause an inherited motor neurone disease (MND) known as ALS4. Our current understanding of MND was revolutionized by the discovery that a protein known as TDP-43 is the main component of protein accumulations found in dying human motor neurones. We have generated a unique mouse model of ALS disease that will be useful for research purposes, but may also prove effective for drug testing.

Funding Amount $AUD 108,466.18

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857