grant

Alpha-2-Macroglobulin and the Transport and Uptake of the Hormone, Hepcidin [ 2010 - 2012 ]

Also known as: The role of alpha-2-macroglobulin on hepcidin transport and uptake

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/632698]

Researchers: Prof Des Richardson (Principal investigator) ,  Dr Yohan Suryo Rahmanto Prof Philip Kuchel

Brief description Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.

Funding Amount $AUD 533,541.03

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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