AGEING. WERNER SYNDROME AND PSEUDOCAPILLARIZATION [ 2009 - 2012 ]

Research Grant

Researchers: Prof David Le Couteur (Principal investigator) ,  A/Pr Victoria Cogger ,  Dr Michel Lebel ,  Prof Robert Mccuskey ,  Prof Ronald Quinn
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Brief description Old age is the main risk factor for atherosclerosis, which is the main cause of mortality and morbidity in the World. We found age-related changes in the microcirculation of the liver called pseudocapillarization that provide a mechanism linking old age with atherosclerosis. Pores in the endothelium called fenestrations disappear, impairing the ability of the liver to breakdown fats. New therapies to treat and prevent age-related pseudocapillarization are being developed.

Funding Amount $AUD 814,108.10

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant