grant

Age-Related Changes in Body Composition and Fuel Metabolism: The Role of Glucocorticoid Signalling in Osteoblasts [ 2016 - 2019 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1101879]

Researchers: Prof Mark Cooper (Principal investigator) ,  Dr Paul Lee Prof Markus Seibel Dr Michael Swarbrick Prof Hong Zhou
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Brief description Our previous studies suggest that age related changes in fat tissue could be due to an increased level of glucocorticoids within bone forming cells (osteoblasts). Mice in which the level of glucocorticoids in osteoblasts is selectively decreased were no different from normal mice at a young age but with ageing were protected against development of obesity and diabetes. This project will examine how bone influences age related changes in fat mass and examine ways in which this might be prevented.

Funding Amount $AUD 846,116.18

Funding Scheme Project Grants

Notes Standard Project Grant

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