Age-Related Changes in Body Composition and Fuel Metabolism: The Role of Glucocorticoid Signalling in Osteoblasts [ 2016 - 2019 ]

Research Grant

Researchers: Prof Mark Cooper (Principal investigator) ,  Dr Michael Swarbrick ,  Dr Paul Lee ,  Prof Hong Zhou ,  Prof Markus Seibel
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Brief description Our previous studies suggest that age related changes in fat tissue could be due to an increased level of glucocorticoids within bone forming cells (osteoblasts). Mice in which the level of glucocorticoids in osteoblasts is selectively decreased were no different from normal mice at a young age but with ageing were protected against development of obesity and diabetes. This project will examine how bone influences age related changes in fat mass and examine ways in which this might be prevented.

Funding Amount $AUD 846,116.18

Funding Scheme Project Grants

Notes Standard Project Grant