grant

Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload [ 2009 - 2012 ]

Also known as: Understanding iron-uptake mechanisms in bacteria to inform strategies to control infection and to treat beta-thalassemia

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/570844]

Researchers: Prof Rachel Codd (Principal investigator)

Brief description In order to establish an infection, bacteria compete with the host for iron, which is in scarce supply. To access iron, bacteria produce compounds called siderophores which bind iron strongly. The iron-siderophore complex, which is unique to each bacterium, is recognised by specific receptors at the bacterial cell-surface and imported for use. In this project, we are using modified siderophores as platforms for bacteria-specific drug design with the aim of producing new antibiotics.

Funding Amount $AUD 275,016.34

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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Affinity-based protein profiling | Antibiotic development | Biomedical and Clinical Sciences | Compounds to treat iron-overload disease | Controlling the formation of biofilms | Dentistry | Development of antibiotics | Fe(III)-siderophore cell-surface receptor proteins | Iron-overload disease and beta-thalassemia | Oral and Maxillofacial Surgery | Siderophores and Fe(III) acquisition in bacteria |
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