Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers [ 2009 - 2012 ]

Research Grant

Researchers: Prof John Mcgrath (Principal investigator) ,  A/Pr Thomas Burne ,  Prof Darryl Eyles ,  Prof Emma Whitelaw

Brief description The offspring of older fathers have an increased risk of developing disorders such as autism and schizophrenia. This is thought to be due to mutations in the developing sperm. Our group has shown in a mouse model that the offspring of older fathers have changes in brain shape and in behaviour, similar to some findings in autism. In this grant we will refine this animal model and explore the brain, behavioural and genetic correlates of advanced paternal age.

Funding Amount $AUD 501,565.34

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant