Additional file 3 of Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Full description

Additional file 3: Supplementary Table S8, Supplementary Table S9, Supplementary Table S10, Supplementary Table S11, and Supplementary Table S12. Supplementary Table S8. Shows the BFDPs under two more restrictive prior probabilities of true association (10-5 and 10-6) for the results presented in Table 1. Supplementary Table S9. Shows the BFDPs under two more restrictive prior probabilities of true association (10-5 and 10-6) for the results presented in Table 2. Supplementary Table S10. Shows power calculation by subgroup, at the two-sided 5E-08 level for varying genotype hazard ratio (GHR) and minor allele frequency (MAF), based on number of cases and event rate from the 15-year breast cancer-specific analyses. Supplementary Table S11. Shows power calculation by subgroup, at the two-sided 5E-08 level for varying genotype hazard ratio (GHR) and minor allele frequency (MAF), based on number of cases and event rate from the 5-year breast cancer-specific analyses. Supplementary Table S12. Shows the subgroup-specific associations detected by previous studies and corresponding estimates from the current study.

Notes

External Organisations
Antoni van Leeuwenhoek Hospital; Queensland Institute of Medical Research; National Institute on Aging; University of Toronto; University of California Berkeley; German Cancer Research Center; Fred Hutchinson Cancer Center; Lund University; University Medical Center Hamburg-Eppendorf; University Hospital Erlangen; University of Cambridge; Ruhr University Bochum; University of Utah; Kaiser Permanente; Roswell Park Cancer Institute; University of Sydney; Mayo Clinic Phoenix; University of Sheffield; Karolinska Institutet; Fox Chase Cancer Center; Hannover Medical School; International Agency for Research on Cancer; University of Westminster; University of Southampton; Harvard University; University of Manchester; University of Copenhagen; Curtin University; University Hospital San Carlos - Hospital Clinico San Carlos; Monash University; University of Oulu; Institut national de la santé et de la recherche médicale; Helmholtz Zentrum München - German Research Center for Environmental Health; University of Cologne; University of Southern California; Stockholm South General Hospital; Mayo Clinic Rochester, MN; University of Eastern Finland; Erasmus MC; University of Tübingen; University of Melbourne; Pomeranian Medical University in Szczecin; University Hospital Ulm; Stanford University; KULeuven BIOTEC; University of Oslo; City of Hope; University of Hawai'i at Mānoa; University of California San Diego; Heraklion University Hospital; University Health Network; University of Helsinki; University of North Carolina at Chapel Hill; Queen's University Belfast; American Cancer Society; Fondazione IRCCS Istituto Nazionale dei Tumori; FIRC Institute of Molecular Oncology; Carmel Medical Center; Puerta de Hierro Majadahonda University Hospital; University College London; University Hospital of Larissa; King's College London; National Center for Tumor Diseases; Saints Cyril and Methodius University of Skopje; Cancer Council Victoria; Institute of Cancer Research; Columbia University; Leiden University; University of Oxford; Uppsala University

Associated Persons
Anna Morra (Creator); Maria Escala-Garcia (Creator); Jonathan Beesley (Creator); Renske Keeman (Creator); Sander Canisius (Creator); Thomas U Ahearn (Creator); Irene L. Andrulis (Creator); Hoda Anton-Culver (Creator); Volker Arndt (Creator); Paul L. Auer (Creator); Annelie Augustinsson (Creator); Laura E. Beane Freeman (Creator); Heiko Becher (Creator); Matthias W. Beckmann (Creator); Sabine Behrens (Creator); Stig E. Bojesen (Creator); Manjeet K. Bolla (Creator); Hermann Brenner (Creator); Thomas Brüning (Creator); Saundra S. Buys (Creator); Bette Caan (Creator); Daniele Campa (Creator); Federico Canzian (Creator); Jose E. Castelao (Creator); Jenny Chang-Claude (Creator); Stephen J. Chanock (Creator); Ting-Yuan David Cheng (Creator); Christine L. Clarke (Creator); Sarah V. Colonna (Creator); Fergus J. Couch (Creator); Angela Cox (Creator); Simon S. Cross (Creator); Kamila Czene (Creator); Mary B. Daly (Creator); Joe Dennis (Creator); Thilo Dörk (Creator); Laure Dossus (Creator); Alison M. Dunning (Creator); Miriam Dwek (Creator); Diana M. Eccles (Creator); Arif B. Ekici (Creator); A. Heather Eliassen (Creator); Mikael Eriksson (Creator); D. Gareth Evans (Creator); Peter A. Fasching (Creator); Henrik Flyger (Creator); Manuela Gago-Dominguez (Creator); José A. García-Sáenz (Creator); Graham G. Giles (Creator); Mervi Grip (Creator); Pascal Guénel (Creator); Melanie Gündert (Creator); Eric Hahnen (Creator); Christopher A. Haiman (Creator); Niclas Håkansson (Creator); Per Hall (Creator); Ute Hamann (Creator); Steven N. Hart (Creator); Jaana M. Hartikainen (Creator); Arndt Hartmann (Creator); Wei He (Creator); Maartje J. Hooning (Creator); Reiner Hoppe (Creator); John L. Hopper (Creator); Anthony Howell (Creator); David J. Hunter (Creator); Agnes Jager (Creator); Anna Jakubowska (Creator); Wolfgang Janni (Creator); Esther M. John (Creator); Audrey Y. Jung (Creator); Rudolf Kaaks (Creator); Machteld Keupers (Creator); Cari M. Kitahara (Creator); Stella Koutros (Creator); Peter Kraft (Creator); Vessela N. Kristensen (Creator); Allison W. Kurian (Creator); James V. Lacey (Creator); Diether Lambrechts (Creator); Loic Le Marchand (Creator); Annika Lindblom (Creator); Martha Linet (Creator); Robert N. Luben (Creator); Jan Lubiński (Creator); Michael Lush (Creator); Arto Mannermaa (Creator); Mehdi Manoochehri (Creator); Sara Margolin (Creator); John W. M. Martens (Creator); Maria Elena Martinez (Creator); Dimitrios Mavroudis (Creator); Kyriaki Michailidou (Creator); Roger L. Milne (Creator); Anna Marie Mulligan (Creator); Taru A. Muranen (Creator); Heli Nevanlinna (Creator); William G. Newman (Creator); Sune Fallgaard Nielsen (Creator); Børge G. Nordestgaard (Creator); Andrew F. Olshan (Creator); Håkan Olsson (Creator); Nick Orr (Creator); Tjoung-Won Park-Simon (Creator); Alpa V. Patel (Creator); Bernard Peissel (Creator); Paolo Peterlongo (Creator); Dijana Plaseska-Karanfilska (Creator); Karolina Prajzendanc (Creator); Ross Prentice (Creator); Nadege Presneau (Creator); Brigitte Rack (Creator); Gad Rennert (Creator); Hedy S. Rennert (Creator); Valerie Rhenius (Creator); Atocha Romero (Creator); Rebecca Roylance (Creator); Matthias Ruebner (Creator); Emmanouil Saloustros (Creator); Elinor J. Sawyer (Creator); Rita K. Schmutzler (Creator); Andreas Schneeweiss (Creator); Christopher G. Scott (Creator); Mitul Shah (Creator); Snezhana Smichkoska (Creator); Melissa C. Southey (Creator); Harald Surowy (Creator); Anthony J. Swerdlow (Creator); Rulla M. Tamimi (Creator); William J. Tapper (Creator); Lauren R. Teras (Creator); Mary Beth Terry (Creator); Rob A. E. M. Tollenaar (Creator); Ian Tomlinson (Creator); Melissa A. Troester (Creator); Thérèse Truong (Creator); Celine M. Vachon (Creator); Qin Wang (Creator); Amber N. Hurson (Creator); Robert Winqvist (Creator); Alicja Wolk (Creator); Argyrios Ziogas (Creator); Hiltrud Brauch (Creator); Montserrat García-Closas (Creator); Paul D. P. Pharoah (Creator); Douglas F. Easton (Creator); Georgia Chenevix-Trench (Creator); Marjanka K. Schmidt (Creator)