Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/607343]Researchers: Dr Fraser Rogerson (Principal investigator) , Prof Amanda Fosang (Principal investigator)
Brief description Cartilage loss is a feature of arthritis and is caused by enzymes. We discovered that loss of a critical cartilage component is caused by the enzyme ADAMTS-5. We also discovered that a mutant form of ADAMTS-5 blocks the normal emzyme, possibly by a novel binding interaction. If we can understand how this interaction works, we can exploit it for the design of new arthritis therapies. This project aims to identify the novel interaction and improve out understanding of cartilage destruction.
Funding Amount $AUD 540,235.87
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 607343
- PURL : https://purl.org/au-research/grants/nhmrc/607343
