grant

Activation and suppression of oncogenic translocation by uracil-DNA glycosylases [ 2013 - 2015 ]

Also known as: Role of uracil-DNA glycosylases in oncogenic translocation

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1051820]

Researchers: Dr Christopher Jolly (Principal investigator) ,  A/Pr Jeffrey Holst ,  Dr Andrew Franklin

Brief description The AID enzyme is implicated in cancer in B lymphocytes and prostate cells. AID causes DNA damage normally recognised by repair enzymes UNG and MutS?, among others. The repair processes these factors initiate involve a DNA break that, if incorrectly re-joined, destabilises the genome, causing cancer. Understanding the function of AID, UNG and MutS? in B cell lymphomas and prostate cancer will provide fundamental insights into cancer and may identify targets for new therapeutics.

Funding Amount $AUD 513,000.33

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
B cells | Biochemistry and Cell Biology | Biological Sciences | Cell Development, Proliferation and Death | DNA repair | lymphoma | mutation | prostate cancer | retrovirus | transgenic model | translocation |
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