Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production [ 2015 - 2018 ]

Research Grant

Researchers: A/Pr Carsten Schmitz-Peiffer (Principal investigator) ,  Prof Trevor Biden

Brief description Our previous studies implicated the enzyme protein kinase C epsilon (PKCe) in the development of fat-induced insulin resistance, a key aspect of Type 2 Diabetes. Contrary to expectations we have now shown that animals lacking PKCe only in fat are protected from whole body insulin resistance when fed a high-fat diet. This project will investigate the mechanisms through which PKCe in fat affects insulin action at other tissues, especially liver, to disrupt normal control of blood sugar levels.

Funding Amount $AUD 906,859.29

Funding Scheme Project Grants

Notes Standard Project Grant