grant

Aberrant oligosaccharide processing of Nox2-oxidase as a mechanism of vascular oxidative stress in atherosclerosis [ 2009 - 2011 ]

Also known as: The addition of sugar chains to Nox2 in vascular disease increases its capacity to generate free radicals

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/545942]

Researchers: Prof Grant Drummond (Principal investigator) ,  Prof Christopher Sobey

Brief description Excessive production of free radicals by an enzyme called Nox2 may be a cause of artery disease leading to heart attacks and strokes. This study will identify whether the addition of sugarchains to Nox2 causes it to be expressed at the surface of cells allowing the free radicals it produces to exit the cell and cause damage to the blood vessel wall. Charaterising this new pathway of excessive free radical production may pave the way for new diagnostics and treatments for artery disease.

Funding Amount $AUD 552,565.34

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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