Is abdominal discomfort a “colonic itch”? Identification of itch specific pathways in the gut in health and disease. [ 2015 - ]

Research Grant

Researchers: A/Pr Stuart Brierley (Principal investigator) ,  Dr Daniel Poole ,  Prof Martin Steinhoff

Brief description Chronic abdominal pain is a major worldwide problem. TGR5 and Mrgpr receptors are expressed by neuronal pathways innervating the skin, where they detect irritants and transmit itch. Our novel, innovative project shows a similar pathway exists within the viscera, which plays a major and unappreciated role in chronic abdominal pain. These receptors represent novel targets for therapeutic treatment, potentially creating multibillion-dollar savings to the Australian economy and healthcare systems.

Funding Amount $873,233.00

Funding Scheme Project Grants

Notes Standard Project Grant