A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules [ 2002-01-01 - 2006-12-31 ]

Research Grant

Researchers: A/Prof Brian May (Chief Investigator) ,  Dr Charles Hii (Partner Investigator)

Brief description A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.

Funding Amount $180,000

Funding Scheme Discovery Projects

View this grant in the ARC Data Portal