Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP0881012]Researchers: A/Prof Filip Braet (Chief Investigator) , Dr Lilian Soon (Chief Investigator) , Professor Rik Thompson (Chief Investigator) , Dr Pascal Vallotton (Partner Investigator)
Brief description A New Model for 3D Migration Involving Claw Structures and Metalloproteinases. This proposal will revolutionize ideas related to cell movement through three-dimensional (3D) matrix. Our method in mimicking the body's dense 3D matrix environment have led to the discovery of a new cell structure called Claws, and the formulation of a new model for 3D invasion in high density matrix. We will study the genes that control this type of migration including those involved in the formation of the cell front (Claw region), the back of the cells and matrix digestion. This work will have significant impact on normal and pathological human conditions from immune responses to tissue regeneration and cancer.
Funding Amount $240,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP0881012
- ARC : DP0881012