A new mechanism of tissue fibrosis - a small peptide regulator of the TGF-beta1/Smad pathway [ 1/1/2021 - 12/31/2023 ]

Research Grant

Brief description Progressive scarring, or fibrosis, of organs leads to their loss of function. Fibrotic diseases are devastating to both the individual and our community and we lack effective therapies. We have identified a small protein, named SPRF, which represents a new mechanism in tissue fibrosis. These studies will examine the role of the SRPF protein in models of kidney, heart and lung fibrosis and its underlying mechanism of action. We will also test a therapy based on inhibiting SPRF function.

Funding Amount $768,757

Funding Scheme Ideas Grants

Chief Investigator Prof David Nikolic-Paterson

Notes Ideas Grants