2-Methoxyestradiol analogues: prototype modulators of annexin II-dependent plasminogen activation [ 2009 - 2011 ]

Research Grant

Researchers: Prof Alastair Stewart (Principal investigator) ,  A/Pr Richard Hughes ,  Prof Martin Banwell ,  Prof Robert Medcalf

Brief description The enzyme system that enables us to dissolve blood clots is similar to the system that enables cancer cells to escape from the primary tumour and travel in the blood to another organ to form a secondary cancer growth. We have new results showing that some drug candidates can distinguish between these two closely related enzyme systems. We are now working to develop inhibitors that will stop cancer cells from spreading without compromising the ability to dissolve blood clots.

Funding Amount $AUD 369,690.04

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant