Data

SNAP Trial Dataset

The University of Melbourne
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Licence & Rights

Restrictive Licence

Dataset description

The SNAP Trial dataset encompasses participant data for patients with Staphylococcus aureus bacteraemia who have been enrolled into either the randomised platform or the registry only data collection component of the SNAP Trial. Global recruitment - current recruiting countries include Australia, Canada, Israel, Singapore, New Zealand, Germany, Netherlands, Sweden, United Kingdom, South AfricaAs an adaptive platform trial with multiple ongoing domains and sub-studies, data will only become available once a trial aspect has reached a conclusion and is reported out. For more information on what data is available for request, please visit the SNAP Trial website (https://www.snaptrial.com.au/for-investigators#interim) or contact the SNAP Trial Project Manager.

Date Information

Created from 2025-06-16
Updated from 2025-06-16
Collected from 2022-02-17/2025-06-03
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Source Study

Purpose:
Not available
Phase:
Not available
Trial acronym

Not available

Trial ID

NCT05137119

Funding

Not available

Scientific enquiries

Brief Summary

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with Staphylococcus Aureus bacteraemia (SAB).

Key Inclusion Criteria

PLATFORM Inclusion Criteria: Patients must fulfil all of the following criteria to be eligible to enter the SNAP trial: 1. Staphylococcus aureus complex grown from =1 blood culture 2. Admitted to a participating hospital at the time of eligibility assessment PLATFORM Exclusion Criteria: Potentially eligible participants meeting any of the following criteria at the time of eligibility assessment for platform entry will be excluded from the trial: 1. Time of anticipated platform entry is greater t .... Read more

Key Exclusion Criteria
Can healthy volunteers participate?

No

Population

Sample Size    Not Available

Min. age    N/A

Max. age    N/A

Sex    All

Condition category    Methicillin-resistant Staphylococcus aureus (MRSA) , Methicillin-susceptible Staphylococcus aureus (MSSA) , Penicillin-susceptible Staphylococcus aureus (PSSA) , S. aureus , Staph Aureus Bacteremia (SAB) , Staphylococcus aureus

Condition code    Staphylococcus Aureus Bacteremia

Intervention

Intervention code Other interventions - Effectiveness of early switch to oral antibiotics , Treatment: Drugs - Cefazolin , Treatment: Drugs - Clindamycin , Treatment: Drugs - Penicillin , Treatment: Drugs - Vancomycin , Treatment: Other - Whole body FDG PET/CT Imaging

Methicillin-resistant staphylococcus aureus (MRSA) - Standard Therapy Arm (backbone therapy) No intervention Vancomycin or Daptomycin - Standard Therapy Arm Either intravenous vancomycin dosed as per Australian Therapeutic Guidelines: This includes a loading dose of 25 mg/kg (up to 3000mg) if considered appropriate by the treating clinician, initial maintenance dosing at 15-20 mg/kg q12h, with subsequent adjustment to maintain area under the concentration-time curve (AUC) of 400 to 600 mg.hr/L O ....
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Comparison

Control group Not available

Comparison not available.

Outcomes

Not Available

The data-sharing statement for this study is currently unavailable.

Source study information is derived from the ClinicalTrials.gov. For more information, please see ClinicalTrials.gov

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