Not available
ACTRN12620001250921
Treatment
Not Applicable
University,Monash University
Dr Caroline Tuck
An therapeutic diet targeting naturally-occurring bioactive chemicals has been suggested to relieve gastrointestinal symptoms. A major focus of this diet is salicylates. This study aimed to address a potential role of dietary salicylates in causing symptoms in patients with irritable bowel syndrome (IBS). A pilot, double-blind, randomised, cross-over trial of two-week low-versus high-salicylate diets was undertaken. All food was provided containing minimal quantities of other potential food trig .... Read more
Patients with irritable bowel syndrome based on Rome III criteria.
- coeliac disease - pregnancy and breastfeeding, - other significant co-morbid conditions such as diabetes and inflammatory bowel disease. - previously received advice or information on a low chemical diet. - taking pharmacological agents like laxatives to alter their symptoms. - taking aspirin or any other drugs containing or delivering salicylates for at least two weeks prior to the commencement of the study.
No
Sample Size 10
Min. age 18 Years
Max. age 75 Years
Sex Both males and females
Condition category Irritable bowel syndrome
Condition code Oral and Gastrointestinal
Intervention code Treatment: Other
Brief name: Low salicylate diet Comparator diet: High salicylate diet (see below) Overall design: This was a pilot, double-blind, randomised, cross-over trial of low versus high-salicylate diets in IBS patients who had no previous exposure to a low chemical diet. Materials: Participants were randomized by a computer-generated order to receive a diet either low or high in salicylate content for 14-days (6.6 and 27.9 g/day salicylate respectively). All food was provided. Participants and investiga .... Read more
Control group Active
Comparator diet: High salicylate diet The average daily intake of salicylates in the high-salicylate diet was 28 mg. The meal plans had an average energy value of 8 MJ daily and met the recommended serves of all food groups according to the Australian dietary guidelines.
Outcome: The primary endpoint was the difference in overall gastrointestinal symptoms measured by the 100-mm Visual Analogue Scale on the low-salicylate diet compared to those on the high-salicylate diet. Timepoint: All comparisons were made using average symptom scores of the last three days of the respective dietary periods.
yes
Individual participant data underlying published results only
Beginning 3 months and ending 5 years following main results publication
On request on a case-by-case basis at the discretion of Primary Sponsor
For IPD meta-analyses