DOMInO
ACTRN12605000569606
Prevention
Phase 4
Government body,NH&MRC
Prof Maria Makrides
DHA is an omega-3 fat found in fish and fish oils and is thought to play a role in the way the brain works and develops. It has been suggested that supplementing the diet with DHA may reduce feelings of depression, while studies with young infants suggest that enriching the diet with DHA may also help improve visual development. While in the womb, the baby is supplied with DHA from the mothers circulation. The level of DHA in the mothers circulation is largely determined by the amount of DHA in .... Read more
Singleton pregnancy of 18-21 weeks gestation; no known fetal abnormality; women with no documented history of alcohol or drug abuse; no participation in other clinical trials with fatty acid intervention.
Bleeding disorders where DHA rich tuna oil is contraindicated.
No
Sample Size 2399
Min. age 0 No limit
Max. age 0 No limit
Sex Females
Condition category Pregnancy
Condition code Reproductive Health and Childbirth
Intervention code Prevention
0.5g DHA rich Tuna Oil Capsules taken from 18-21 weeks until birth.
Control group Placebo
0.5g Blended vegatable oil capsules
Outcome: Symptoms of postnatal depressionTimepoint: At 6 weeks and 6 months post partum
yes
De-identified, individual participant data (IPD) that underlie the results reported in the primary paper (text, tables, figures and appendices) will be available. Dataset(s) will be limited to those participants and variables that are necessary for completion of the approved research proposal.
Available after publication with no end date determined
Data will be available to researchers who provide a methodologically sound research proposal following review and approval by the trial steering committee and completion of a signed data access agreement
Data may be shared with researchers who provide a methodologically sound research proposal following review and approval by the trial steering committee and completion of a signed data access agreement